Bone strength beyond BMD: The importance of bone quality

After menopause, both bone quantity and quality decrease, compromising overall bone strength1*

BMD icon

BMD determined by DXA provides a measure of bone quantity, but
cannot capture three-dimensional bone geometry or microarchitecture2

Bone Architecture Icon

A study suggested that bone microstructure predicted low-trauma fractures
in postmenopausal women who would not have qualified as high risk
for fracture according to DXA or FRAX scores3†

A study suggested that detection of altered bone microstructure and strength
may further identify patients at imminent fracture risk3†

Learn more about the risk of subsequent fractures following a fracture

Learn more about the risk of subsequent fractures following a fracture

Bone strength is determined by structural properties (geometry and microarchitecture) and material properties (mineral, collagen, and microdamage/microfracture).4

A prospective cohort study of 740 postmenopausal women from the Geneva Retirees Cohort evaluated whether bone microstructure and strength assessment
improve fracture prediction beyond central aBMD, TBS, and FRAX.3

DXA=dual-energy X-ray absorptiometry; FRAX=fracture risk assessment tool; aBMD=areal BMD; TBS=trabecular bone score.

References: 1. Seeman E, Delmas PD. Bone quality—the material and structural basis of bone strength and fragility. N Engl J Med. 2006;354(21):2250-2261. 2. Unnanuntana A, Gladnick BP, Donnelly E, Lane JM. The assessment of fracture risk. J Bone Joint Surg Am. 2010;92(3):743-753. 3. Biver E, Durosier-Izart C, Chevalley T, van Rietbergen B, Rizzoli R, Ferrari S. Evaluation of radius microstructure and areal bone mineral density improves fracture prediction in postmenopausal women [published online ahead of print September 28, 2017]. J Bone Miner Res. doi:10.1002/jbmr.3299. 4. Felsenberg D, Boonen S. The bone quality framework: determinants of bone strength and their interrelationships, and implications for osteoporosis management. Clin Ther. 2005;27(1):1-11.

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This site is intended for HCPs in the United States.
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All other trademarks are the property of their respective owners.

© 2018 Radius Health, Inc.
All rights reserved. 04/18.
TYM-US-01391

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