Fragility fracture is an
indicator of high risk1

Osteoporosis can be diagnosed in clinical practice based on presence
and/or history of fragility fractures2,3*†

Data showing increased risk for subsequent osteoporotic fractures in postmenopausal women

In postmenopausal women aged 50 years and older, an osteoporotic
fracture is a sentinel event that could lead to subsequent fractures6-8

Fractures that occur with minimal trauma, such as a fall from standing height or less.9

Fragility fractures of the spine or hip, regardless of BMD; fragility fractures of the proximal humerus, pelvis, or possibly distal forearm with osteopenia or low bone mass (T-score between -1 and -2.5).3

The longitudinal, observational National Osteoporosis Risk Assessment (NORA) study of 149,524 white postmenopausal women aged 50 years and older examined reported fractures in the year following BMD measurement.5

The first 12 months after an osteoporotic fracture: a critical intervention period7,8

In the year following an osteoporotic fracture, postmenopausal women
are at heightened risk for subsequent fractures7,8

In the year following an osteoporotic fracture, postmenopausal women
are at heightened risk for subsequent fractures7,8

Incidence of new vertebral fracture in first year of study7*

Graphic showing the incidence of new vertebral fracture in first year of study

The impact of non-hip NONVERTEBRAL (NHNV) fractures is often underestimated10

In women aged 50 to 64 years, NHNV fractures were 12x more common than hip fractures and 10x more common than vertebral fractures11*

Studies have shown an increased risk for subsequent hip fracture after other NHNV fracture8,12:

NHNV fractures are an early warning sign that more serious fractures may be next10,13

A retrospective study based on Thomas Reuters MarketScan® Commercial Claims and Encounters, and Medicare Supplemental and Coordination of Benefit Databases of patients (aged 50 years and older) with closed hip, vertebral, or NHNV (pelvis, humerus, wrist, clavicle, leg) fracture between 2001 and 2004 who were continuously enrolled 6 months prior to and 12 months after the fracture.11

A prospective, multicenter cohort of 8049 white women aged 65 years and older from the Study of Osteoportic Fractures was followed for a mean of 9.8 years to evaluate the relationship between proximal humerus fractures and hip fractures.8

An analysis of postmenopausal women (N=158,940) aged ≥50 years from the NORA prospective study who provided history of wrist fracture to determine future fracture risk.12

Learn more about anabolics and antiresorptives

Learn more about anabolics and antiresorptives

References: 1. Trémollieres FA, Pouillès JM, Drewniak N, Laparra J, Ribot CA, Dargent-Molina P. Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: sensitivity of the WHO FRAX tool. J Bone Miner Res. 2010;25(5):1002-1009. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112173. Accessed April 3, 2018. 2. van den Bergh JP, van Geel TA, Geusens PP. Osteoporosis, frailty, and fracture: implications for case finding and therapy. Nat Rev Rheumatol. 2012;8(3):163-172. 3. Camacho PM, Petak SM, Binkley N, et al. American Association of Clinical Endocrinologists and American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis—2016. Endocr Pract. 2016;22(suppl 4):1-42. 4. Kanis JA, Johnell O, Oden A, et al. Long-term risk of osteoporotic fracture in Malmö. Osteoporos Int. 2000;11(8):669-674. 5. Siris ES, Brenneman SK, Miller PD, et al. Predictive value of low BMD for 1-year fracture outcomes is similar for postmenopausal women ages 50-64 and 65 and older: results from the National Osteoporosis Risk Assessment (NORA). J Bone Miner Res. 2004;19(8):1215-1220. 6. National Coalition for Osteoporosis and Related Bone Diseases. National Action Plan for Bone Health: Recommendations From the Summit for a National Action Plan for Bone Health. http://www.oif.org/site/DocServer/BoneHealthReport.pdf. Accessed April 3, 2018. 7. Lindsay R, Silverman SL, Cooper C, et al. Risk of new vertebral fracture in the year following a fracture. JAMA. 2001;285(3):320-323. 8. Clinton J, Franta A, Polissar NL, et al. Proximal humeral fracture in the year following a fracture. JAMA. 2001;285(3):320-323. 9. Giangregorio L, Papaioannou A, Thabane L, et al. Do patients perceive a link between a fragility fracture and osteoporosis? BMC Musculoskelet Disord. 2008;9:38. 10. Bliuc D, Nguyen TV, Eisman JA, Center JR. The impact of nonhip nonvertebral fractures in elderly women and men. J Clin Endocrinol Metab. 2014;99(2):415-423. 11. Shi N, Foley K, Lenhart G, Badamgarav E. Direct healthcare costs of hip, vertebral, and non-hip, non-vertebral fractures. Bone. 2009;45(6):1084-1090. 12. Barrett-Connor E, Sajjan SG, Siris ES, Miller PD, Chen Y-T, Markson LE. Wrist fracture as a predictor of future fractures in younger versus older postmenopausal women: results from the National Osteoporosis Risk Assessment (NORA). Osteoporos Int. 2008;19(5):607-613. 13. Center JR. The definition and clinical significance of nonvertebral fractures. Curr Osteoporos Rep. 2010;8(4):227-234.

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All other trademarks are the property of their respective owners.

© 2019 Radius Health, Inc.
All rights reserved. 10/19.
TYM-US-02916

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