Fragility fracture is an
indicator of high risk1

Osteoporosis can be diagnosed in clinical practice based on presence
and/or history of fragility fractures2,3*†

Data showing increased risk for subsequent osteoporotic fractures in postmenopausal women

In postmenopausal women aged 50 years and older, an osteoporotic
fracture is a sentinel event that could lead to subsequent fractures6-8

Fractures that occur with minimal trauma, such as a fall from standing height or less.9

Fragility fractures of the spine or hip, regardless of BMD; fragility fractures of the proximal humerus, pelvis, or possibly distal forearm with osteopenia or low bone mass (T-score between -1 and -2.5).3

The longitudinal, observational National Osteoporosis Risk Assessment study of 149,524 white postmenopausal women aged 50 years and older examined reported fractures in the year following BMD measurement.5

The first 12 months after an osteoporotic fracture: a critical intervention period6-8

In the year following an osteoporotic fracture, postmenopausal women
are at heightened risk for subsequent fractures6-8

In the year following an osteoporotic fracture, postmenopausal women
are at heightened risk for subsequent fractures6-8

Incidence of new vertebral fracture in first year of study6*

Graphic showing the incidence of new vertebral fracture in first year of study

After a proximal humerus fracture, women aged 65 years and older were at 6x the risk for a subsequent 
hip fracture within 1 year. The significance of the association did not continue beyond 1 year in this study8||

See how anabolics work

See how anabolics work

A prospective multicenter cohort of 8049 white women aged 65 years and older from the Study of Osteoporotic Fractures was followed for a mean of 9.8 years to evaluate the relationship between proximal humerus fractures and hip fractures.8

References: 1. Trémollieres FA, Pouillès JM, Drewniak N, Laparra J, Ribot CA, Dargent-Molina P. Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: sensitivity of the WHO FRAX tool. J Bone Miner Res. 2010;25(5):1002-1009. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112173. Accessed April 3, 2018. 2. van den Bergh JP, van Geel TA, Geusens PP. Osteoporosis, frailty, and fracture: implications for case finding and therapy. Nat Rev Rheumatol. 2012;8(3):163-172. 3. Camacho PM, Petak SM, Binkley N, et al. American Association of Clinical Endocrinologists and American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis—2016. Endocr Pract. 2016;22(suppl 4):1-42. 4. Kanis JA, Johnell O, Oden A, et al. Long-term risk of osteoporotic fracture in Malmö. Osteoporos Int. 2000;11(8):669-674. 5. Siris ES, Brenneman SK, Miller PD, et al. Predictive value of low BMD for 1-year fracture outcomes is similar for postmenopausal women ages 50-64 and 65 and older: results from the National Osteoporosis Risk Assessment (NORA). J Bone Miner Res. 2004;19(8):1215-1220. 6. Lindsay R, Silverman SL, Cooper C, et al. Risk of new vertebral fracture in the year following a fracture. JAMA. 2001;285(3):320-323. 7. National Coalition for Osteoporosis and Related Bone Diseases. National Action Plan for Bone Health: Recommendations From the Summit for a National Action Plan for Bone Health. http://www.oif.org/site/DocServer/BoneHealthReport.pdf. Accessed April 3, 2018. 8. Clinton J, Franta A, Polissar NL, et al. Proximal humeral fracture in the year following a fracture. JAMA. 2001;285(3):320-323. 9. Giangregorio L, Papaioannou A, Thabane L, et al. Do patients perceive a link between a fragility fracture and osteoporosis? BMC Musculoskelet Disord. 2008;9:38.

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This site is intended for HCPs in the United States.
TYMLOS is a registered trademark of Radius Health, Inc.
All other trademarks are the property of their respective owners.

© 2018 Radius Health, Inc.
All rights reserved. 12/18.
TYM-US-02038

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